The Choice of Dry Eye Therapy Depending on Ocular Surface Condition

Purpose : to develop approaches differentiated substitution therapy in patients with dry eye (DE) of mild and moderate severity. Patients methods . We examined 86 DE (22–45 years old; 38 men, 48 women). Group-1 included 54 (54 eyes) under conditions combined lipid-mucose-deficiency, group-2 32 (32 against the background lipid-aqua-mucose-deficiency. Conducted: symptoms registration (OSDI scale); Norn Shirmer-1 tests; OCT meniscometry; assessment Bijsterveld xerosis index ‘lid-vipers’ symptom identification; Norn’s compression test. To effectiveness, both groups were divided into subgroups. subgroup 1.1 (18 carried out ‘fat-water’ type emulsion instillations, 1.2 — 0.15 % sodium hyaluronate instillation (Hylabak®), 1.3 3.0 trehalose (Thealoz®) 1–2 drops, 4 times a day. All persons group-1 additionally recommended apply 5.0 dexpanthenol gel at night. 2.1 (16 received 2.2 (Hylabak®) ointment vitamin A The main criterion for effectiveness was tear film brake up time (TBUT, s) two months after start treatment. Statistical processing included: calculation mean its standard deviation (M ± s); significance differences (Wilcoxon’s t-test, KruskalWallis test, Mann-Whitney U-test). Results In following TBUT dynamics recorded: from 5.4 0.5 6.2 0.6 s (p < 0.05); 5.2 0.4 6.6 5.3 7.1 0.7 0.05). most pronounced increase noted (trehalose instillation). group-2, was: 3.5 0.3 4.7 3.4 0.2 significantly more (sodium Conclusion our opinion, replacement may be lipid-mucose-deficiency bioprotector based on (Thealose®); case lipid-aqua-mucose-deficiency combination (Thealoz®).